Research
Research
The research behind every dose
We would rather show you the studies than ask you to take our word for it.
NEW ME formulas are built on published, peer-reviewed human research, and dosed to match the amounts used in those trials. Below is the science behind each active ingredient, in plain language, with every study linked so you can read it yourself.
Our research philosophy
We formulate to the doses used in published human trials
Most supplements sprinkle a fashionable ingredient in at a fraction of the researched amount, then borrow the headlines from studies that used far more. We do the opposite. When the clinical literature shows a benefit at 2000 mg of myo-inositol or 1000 mg of berberine, that is the amount we put in the sachet or the serving, not a fairy-dust trace. Where the research is strong, we say so plainly. Where it is still building, we keep our language soft and honest. That is the whole brand.
These are studies of the ingredients, not studies of NEW ME products. The research below was conducted by independent scientists on the individual compounds in our formulas, myo-inositol, D-chiro-inositol, berberine, apple cider vinegar and more. We have not run our own clinical trials on the finished NEW ME products, and we do not claim the studies were performed on them. We share this research because we dose our formulas to the amounts these trials used, and because you deserve to see the evidence for yourself. Individual results vary, and a supplement is not a substitute for medical care.
Every finding on this page uses structure/function language, how an ingredient supports a normal, healthy body, never a claim to diagnose, treat, cure or prevent any disease.
The evidence, ingredient by ingredient
Study cards
Grouped by the active ingredient in each formula. Each card gives the finding in plain English, the study design and population where known, and a link to the study on PubMed.
Myo & D-chiro Inositol (40:1)
2000 mg myo + 50 mg D-chiro In HarmonyWomen taking inositol were 1.79× more likely to have a regular menstrual cycle than those on placebo, alongside healthier testosterone and glucose readings.
Systematic review of 26 randomized controlled trials in 1,691 women, 2023.
Greff D, et al. Reproductive Biology and Endocrinology, 2023. PMID 36703143
In a head-to-head comparison of seven different myo-to-D-chiro inositol ratios, the 40:1 ratio, the exact ratio in Harmony, was the most effective for supporting healthy ovulatory function.
Clinical comparison of seven inositol ratios.
Nordio M, et al. Eur Rev Med Pharmacol Sci, 2019. PMID 31298405
Myo-inositol significantly improved the HOMA insulin-resistance index versus control, with sex-hormone-binding balance improving at 24 weeks of daily use.
Meta-analysis of 7 randomized trials, 2017.
Unfer V, et al. Endocrine Connections, 2017. PMID 29042448
70% of women restored ovulation while taking myo-inositol as part of the studied protocol.
Clinical study in women with cycle irregularity.
Papaleo E, et al. Gynecol Endocrinol, 2007. PMID 17952759
Daily myo-inositol significantly improved insulin sensitivity and lowered the HOMA insulin-resistance index over the study period.
Clinical trial in women with metabolic and hormonal concerns, 2012.
Genazzani AD, et al. Gynecol Endocrinol, 2012. PMID 22612517
Magnesium Glycinate & Vitamin B8
150 mg magnesium + 50 mg B8 In HarmonySupporting nutrients, an honest note
Magnesium (as glycinate) and Vitamin B8 are included to support natural energy and a balanced, calm mood through the day. Vitamin B8 is itself a form of inositol, so it adds to the inositol story above. We are not linking individual clinical trials for these two nutrients here, because the strong, headline-grade published research in our formulas sits with the hero actives, inositol, berberine and apple cider vinegar. We would rather be transparent about that than dress up supporting ingredients with borrowed studies.
Berberine HCl
1000 mg per daily serving In BurnBerberine significantly supported healthy fasting and post-meal glucose levels versus control.
Meta-analysis of 50 randomized trials, 4,150 participants, 2024.
Wang J, et al. Frontiers in Pharmacology, 2024. PMID 39640489
Berberine was associated with roughly a 45% improvement in the HOMA-IR insulin-resistance index.
Clinical trial in adults with metabolic concerns, 2008.
Yin J, et al. 2008. PMID 18442638
36% lower triglycerides over a three-month trial.
Three-month clinical trial.
Zhang Y, et al. 2008. PMID 18397984
Berberine activates AMPK, the cell's energy sensor, helping move glucose into muscle cells for energy.
Mechanistic laboratory research.
Lee YS, et al. Diabetes, 2006. PMID 16873688
Berberine supported reductions in BMI and waist circumference, with longer use associated with greater benefit.
Dose-response meta-analysis of 10 trials, 2020.
Xiong P, et al. Complement Ther Clin Pract, 2020. PMID 32379652
In women with PCOS and insulin resistance, berberine supported insulin sensitivity with no significant difference versus metformin.
Meta-analysis of 9 trials, 2018.
Li MF, et al. Evid Based Complement Alternat Med, 2018. PMID 30538756
Apple Cider Vinegar (acetic acid)
Sugar-free ACV with chromium & antioxidants In GlowVinegar taken with a carbohydrate meal significantly blunted the post-meal glucose and insulin spike, in both healthy people and those with glucose concerns.
Controlled human trials.
Shishehbor F, et al. Diabetes Res Clin Pract, 2017. PMID 28292654
Adding vinegar to a meal lowered its glycemic impact by about 35% and raised feelings of fullness in a dose-dependent way.
Controlled meal-study in healthy adults, 2005.
Östman E, et al. Eur J Clin Nutr, 2005. PMID 16015276
A daily vinegar dose supported modest reductions in body weight, waistline and triglycerides versus placebo, as part of a calorie-aware lifestyle.
12-week trial in 155 adults, 2009.
Kondo T, et al. Biosci Biotechnol Biochem, 2009. PMID 19661687
Vinegar works partly by slowing stomach emptying, which supports a longer-lasting feeling of fullness after meals.
Controlled human study, 2007.
Hlebowicz J, et al. BMC Gastroenterology, 2007. PMID 18093343
Chromium
Included in Glow In GlowSupporting nutrient, an honest note
Chromium is included in Glow as a supporting mineral that contributes to normal macronutrient metabolism. We are not citing a specific clinical trial for it here, the strong, headline research in our formulas sits with the hero actives above. We keep chromium in the formula for its recognized role in normal metabolism, and we would rather be honest about the difference than borrow studies it did not run in.
Formulation
How we choose our doses
Three simple rules decide what goes into every NEW ME formula, and how much.
Match the trials
We look at the amount used in the published human research, then dose to it, 2000 mg myo-inositol in the 40:1 ratio, 1000 mg berberine per serving. No under-dosing to save cost.
Transparent labels
Every active and its amount is printed on the Supplement Facts panel. No proprietary-blend hiding, no fillers you did not ask for. What is on the label is what is in the sachet.
Clean & heat-stable
Sugar-free, non-GMO, and made to GMP, HACCP and ISO standards, and formulated to stay stable in the Gulf climate, so the dose you read is the dose you get.
Honest expectations
What supplements can't do
We believe honesty converts better than hype, and it is simply the right way to talk to you. So here is what these formulas are not:
- They are not magic pills. No supplement melts fat, cures PCOS, or replaces medical treatment.
- They are not a diet or a shortcut. They support a healthy lifestyle, balanced meals, movement, sleep, they do not stand in for it.
- They are not medication, and they are not a GLP-1 injection. They work with your body's own metabolic and hormonal pathways.
- They are not instant. The research shows benefits build with consistent daily use over weeks to a few months.
- They are not right for everyone. If you are pregnant, breastfeeding, or taking medication (including diabetes medication), talk to your doctor first.
What they can do is give your body clean, correctly-dosed, well-researched ingredients to support insulin sensitivity, hormonal balance, healthy metabolism and comfortable digestion, every single day.
See the ingredients. Then feel the difference.
Explore exactly what goes into each formula, or start your own 60-day reset today. Love it or your money back.
The research on this page was conducted by independent scientists on individual ingredients, not on NEW ME products, and is shared for educational purposes. These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease. Consult your physician before use if you are pregnant, breastfeeding, taking medication (including diabetes medication), or managing a medical condition. Results vary from person to person.